A Phase I/IIa Clinical Trial of a Recombinant Rho Protein Antagonist in Acute Spinal Cord Injury
نویسندگان
چکیده
منابع مشابه
A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury.
Multiple lines of evidence have validated the Rho pathway as important in controlling the neuronal response to growth inhibitory proteins after central nervous system (CNS) injury. A drug called BA-210 (trademarked as Cethrin(®)) blocks activation of Rho and has shown promise in pre-clinical animal studies in being used to treat spinal cord injury (SCI). This is a report of a Phase I/IIa clinic...
متن کاملUsing recombinant Rho protein antagonist in acute spinal cord injury; does this go further from conventional decompressions?
New evidence has suggested the Rho signaling pathway as a target for treatment in acute spinal cord injury (SCI). The Rho signaling pathway plays an important role in neuronal growth inhibition after a CNS injury. Block of Rho pathway is a new potential method to improve recovery after an SCI. Other studies by our group had further revealed the underlying mechanisms of this pathway (Firouzi et ...
متن کاملCell Therapy in Spinal Cord Injury: a Mini- Reivew
Spinal cord injury (SCI) is a debilitating disease which leads to progressive functional damages. Because of limited axonal regeneration in the central nervous system, there is no or little recovery expected in the patients. Different cellular and molecular approaches were investigated in SCI animal models. Cellular transplantation of stem cells can potentially replace damaged tissue and provid...
متن کاملA Case of Gunshot Injury to the Spinal Cord in a Dog: Clinical, Surgical, and X-ray Features.
Case description- A five-year-old female dog, weighing 35 kg, was presented as an emergency case after it suffered a gunshot injury.Clinical findings - Physical examination of the dog revealed paraplegia, the symptoms were normal. There was no bone fracture and dislocation in the lower extremity examination. A bullet (diameter, 4 mm) between the third and fourth lumbar was observed on rad...
متن کاملOptimizing Clinical Decision Making in Acute Traumatic Spinal Cord Injury
Spinal cord injury (SCI) is a devastating event causing lifelong disability that results in a significant decrease in quality of life and immense cost to the health care system, individuals and their families. Providing specialized and timely care can improve recovery and reduce costs, but to make this a reality requires understanding of the current care delivery processes and the care journey....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurotrauma
سال: 2011
ISSN: 0897-7151,1557-9042
DOI: 10.1089/neu.2011.1765